Grape compound in red wine may help heal liver injury
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Scientists have found that resveratrol can act as a potential therapeutic drug for ischemia-reperfusion related liver injury.
Hepatic injury caused by ischemia/reperfusion (I-R) has been proposed as a key clinical problem associated with liver transplantation and major liver surgery.
Resveratrol is found in the skin of red grapes and is a constituent of red wine.
Reperfusion injury is characterised by the production of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radical.
Resveratrol has been reported to have several biologic effects such as a potent antioxidative effect via prevention of lipid peroxidation.
Researchers led by Ercan Gedik from Turkey used biochemical and histological parameters to evaluate the possible protective effect of resveratrol against I-R-induced hepatic injury.
The study was conducted on a total of 40 male Sprague-Dawley rats weighing 240-290 g and they were randomized into four groups of ten- controls: data from unmanipulated animals; sham group: rats subjected to the surgical procedure, except for liver I-R, and given saline; I-R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 minutes; I-R Resveratrol group: rats pretreated with resveratrol.
The researcher studied serum liver enzymes and histological changes in all the groups.
They found that Plasma aminotransferase activities were higher in the I-R group than in the I-R/Resveratrol group.
Also, the researchers observed that Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3.
In group 4, histopathological changes were significantly attenuated in resveratrol treated livers.
The results indicated that resveratrol has protective effects against hepatic I-R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury
The study was published in a recent issue of the World Journal of Gastroenterology. (ANI)
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David Hynes said:
The wonder ingredient in wine is resveratrol. Dr. David Sinclair, Associate Professor of Pathology and Co-Director of the
Laboratories for the Biological Mechanisms of Aging at Harvard Medical School is the leader in research into the anti-aging
properties of resveratrol. The current studies performed by Dr. Sinclair and many other researchers have shown great promise
for resveratrol treating the diseases of aging. There are numerous articles that I have linked to at my website –
http://resveratrol.webiage.com – that document the findings for the potential health benefits in treating heart disease, cancer, diabetes, osteoporosis,
obesity, and other diseases.
Concerning supplements containing a high quality and potency of resveratrol that is necessary to achieve the dosage levels
utilized in the lab tests, there is a new product called Vivix. Shaklee Corporation, the number one natural nutrition company
in the U.S. (http://www.shaklee.com/index.shtml), has produced a liquid resveratrol supplement that is 10 times stronger than
resveratrol alone due to its patented formulation of polyphenols.
Oprah Winfrey and Dr. Oz are both users and promoters of Shaklee products and Oprah has featured Roger Barnett, Chairman and
CEO of Shaklee (http://www.shaklee.com/company_lead_ceo.shtml), on her show.
So for a highly researched resveratrol supplement of exceptional quality, please visit –
http://www.shaklee.net/davidhynes/vivix – to discover more about Vivix.January 2nd, 2009 at 12:35 am
